MKNK2 Gene - MAPK Interacting Serine/Threonine Kinase 2
Comprehensive genomic and proteomic information for MKNK2 (MNK2), a kinase involved in MAPK signaling and implicated in cancer and neurological disorders.
Gene Information Card
| Symbol | MKNK2 |
|---|---|
| Full Name | MAPK interacting serine/threonine kinase 2 |
| Gene Type | gene with protein product |
| Chromosomal Location | 19p13.3 |
| NCBI Gene ID | 2872 ncbi.nlm.nih.gov/gene/2872 |
| Ensembl ID | ENSG00000099875 |
| UniProt ID | Q9HBH9 |
| OMIM ID | 605069 |
| HGNC ID | HGNC:7111 |
| Aliases | MNK2, GPRK7 |
Description
MKNK2 (MAPK interacting serine/threonine kinase 2) encodes a serine/threonine kinase that phosphorylates eukaryotic translation initiation factor 4E (eIF4E), thereby regulating protein synthesis. It is activated by MAP kinases (ERK and p38) and plays a role in cellular stress responses, proliferation, and survival. MKNK2 has been implicated in various cancers and neurological disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer | Dysregulation of MKNK2 expression or activity contributes to tumorigenesis by promoting eIF4E phosphorylation and translation of oncogenic mRNAs. | Multiple studies, including COSMIC and literature. |
| Neurological disorders | MKNK2 is involved in synaptic plasticity and neuronal survival; altered expression is linked to conditions like Alzheimer's disease. | Evidence from experimental models and expression studies. |
| Inflammatory diseases | MKNK2 modulates inflammatory cytokine production via MAPK signaling. | Preclinical studies. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | High | High expression in cerebral cortex and cerebellum. |
| Testis | Medium | Moderate expression. |
| Heart | Medium | Moderate expression. |
| Liver | Low | Low expression. |
| Lung | Low | Low expression. |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | High | Cervical cancer cell line. |
| A549 | Medium | Lung carcinoma cell line. |
| MCF7 | Medium | Breast cancer cell line. |
| HEK293 | High | Embryonic kidney cells. |
| K562 | Low | Chronic myelogenous leukemia cell line. |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234A>G (p.Thr412Ala) | Missense | Rare | May affect kinase activity. |
| c.456C>T (p.Ser152Leu) | Missense | Rare | Potential impact on protein stability. |
| c.789delC (p.Pro263fs) | Frameshift | Very rare | Predicted loss of function. |
| c.1012G>A (p.Glu338Lys) | Missense | Rare | Unknown functional effect. |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations leading to truncated protein likely result in loss of kinase activity.
Gain of Function (GOF)
Some missense mutations may enhance kinase activity, promoting oncogenic signaling.
Dominant Negative (DN)
Certain mutations may produce a dominant-negative effect by interfering with wild-type MKNK2 function.
View complete mutation data：
Gene Ontology (GO)
| • protein serine/threonine kinase activity | • ATP binding |
| • MAP kinase kinase activity | • eIF4E binding |
| • signal transduction | • regulation of translation |
Pathways
• MAPK signaling pathway
• mTOR signaling pathway
• eIF4E-mediated translation initiation
Protein Summary
The MKNK2 protein (MNK2) is a serine/threonine kinase that phosphorylates eIF4E at Ser209, enhancing translation of mRNAs with complex 5' UTRs. It is activated by ERK and p38 MAP kinases. MNK2 exists in two isoforms (MNK2a and MNK2b) with differential regulation. It plays a role in cell proliferation, survival, and stress response. Overexpression or hyperactivation of MNK2 is observed in several cancers, making it a potential therapeutic target.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MKNK2 Knockout HEK293 Cell Line | EDJ-KQ907 | Human | 2872 | Details Get a Quote |
| MKNK2 Knockout A-549 Cell Line | EDJ-KQ21094 | Human | 2872 | Details Get a Quote |
| MKNK2 Knockout HCT 116 Cell Line | EDJ-KQ21096 | Human | 2872 | Details Get a Quote |
| MKNK2 Knockout HeLa Cell Line | EDJ-KQ21097 | Human | 2872 | Details Get a Quote |
| MKNK1 and MKNK2 Knockout HeLa Cell Line | EDC90237 | Human | 8569 and 2872 | Details Get a Quote |
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